Reactions of Tertiary Amines with N-Bromosuccinimide

Biological activity of new N-oxides of tertiary amines.

Potential biological properties of newly synthesized single and double alkyl chain N-oxides of tertiary amines (NTA) were studied. Individual compounds in each of the series had alkyl chains of different length. Various experiments were performed to determine a mechanism of the interaction between NTA and model and biological membranes. These were measurements of hemolytic efficiencies of NTA (...

Solid-phase synthesis of tertiary N-methyl amines including tropanes.

Synthesis on solid phase is one of modern methodologies especially useful in parallel and combinatorial syntheses. Tertiary amine functionalities are found in many important classes of catalysts, reagents and biologically active compounds. The tertiary N-methyl group is also present in structures of tropane alkaloids and majority of synthetic tropane derivatives with potential biological activi...

Bromoform reaction of tertiary amines with N,N-dibromosulfonamides or NBS/sulfonamides.

A new bromoform reaction of tertiary amines with N,N-dibromosulfonamides or NBS/sulfonamides has been developed. A series of amidines were prepared with moderate to good yields via a Csp(3)-Csp(3) bond cleavage.

Chemical modification of ribonucleic acid polymerase with N-bromosuccinimide.

The mechanism of specific interaction between a protein and a nucleic acid is thought to reside partially in the arrangement and types of amino acid present in the protein. Attempts have been made to assign specific roles in this interaction to certain amino acids, for example, tryptophan and tyrosine are thought to be involved in unwinding the double helix of DNA (Brun et al., 1975), and in se...

Flow injection chemiluminescence determination of N-bromosuccinimide and N-chlorosuccinimide.